The philosophical debate about free will and responsibility has been of great importance throughout the history of philosophy. In modern times this debate has received an enormous resurgence of interest and the contribution in 1962 by P.F. Strawson with the publication of his essay "Freedom and Resentment" has generated a wide range of discussion and criticism in the philosophical community and beyond. The debate is of central importance to recent developments in the free will literature and has shaped the way (...) contemporary philosophers now approach the problem. This volume brings together a focused selection of the major contributions and reactions to the free will and responsibility debate inspired by Strawson's contribution. McKenna and Russell also provide a comprehensive overview of the debate. (shrink)

In this paper, we offer reasons to justify the explanatory credentials of dynamical modeling in the context of the metaplasticity thesis, located within a larger grouping of views known as 4E Cognition. Our focus is on showing that dynamicism is consistent with interventionism, and therefore with a difference-making account at the scale of system topologies that makes sui generis explanatory differences to the overall behavior of a cognitive system. In so doing, we provide a general overview of the interventionist approach. (...) We then argue that recent mechanistic attempts at reducing dynamical modeling to a merely descriptive enterprise fail given that the explanatory standard in dynamical modeling can be shown to rest on interventionism. We conclude that dynamical modeling captures features of nested and developmentally plastic cognitive systems that cannot be explained by appeal to underlying mechanisms alone. (shrink)

We describe an evaluation undertaken on contract for the New Zealand State Services Commission of a major project (the Administrative Decision-Making Skills Project) designed to produce a model of administrative decision making and an associated teaching/learning packagefor use by government officers. It describes the evaluation of a philosophical model of decision making and the associated teaching/learning package in the setting of the New Zealand Public Service, where a deliberate attempt has been initiated to improve the quality of decision making, especially (...) in relation to moral factors. (shrink)

The dissertation begins with a question: Are the mind and brain the same or different? -/- I spend Chapter 1 showing how this simple question leads to a philosophical puzzle known as the mind-body problem. By way of explaining the puzzle, I show that there are two demands that a satisfactory solution to the puzzle must meet – what I call the Ontological and Explanatory Demands. I also explain why ontological idealism is not an attractive solution to the problem. Along (...) the way, I refine the starting question into something more familiar to current discussions of the mind-body problem: Are phenomenal properties fundamentally the same or fundamentally different from physical properties? -/- Chapter 2 develops the impasse that contemporary philosophers find themselves in by discussing the Causal Argument against dualism and the Epistemic Argument against materialism. Neither materialism nor dualism seem capable of meeting both demands from Chapter 1. Thus, the rest of the dissertation is an exploration of a fourth, non-standard solution – neutral monism – that hopes to meet these demands. -/- Chapter 3 shows how the most popular way to develop neutral monism, called Russellian monism, does not work. The basic problem is that most ways to develop this view falls to a dilemma such that it is either incoherent or really just one of the more standard solutions to the puzzle in new dressing. The final two options – Reductionist Russellian Monism and Epistemic Russellian Monism – have the capacity to accomplish the goal of neutral monism, but the uniquely Russellian aspects of the views do nothing to help accomplish this. As such, I leave Russellian monism behind and focus on non-Russellian views. -/- Chapter 4 argues that reductionist neutral monism cannot work. Since it relies on reductionism, it faces a different dilemma. Either the phenomenal can be reduced or it cannot. If it cannot, then obviously reductionist neutral monism is false. If it can, then there is no motivation for supposing that it reduces to some neutral stuff rather than reducing to the physical. So, the only possibility is to attempt to develop an epistemic neutral monism. I spend the majority of the chapter explaining what this style of solution might look like, paying close attention to very similar types of answers known as a posteriori physicalism and the powerful qualities view. The result is that epistemic neutral monism as standardly employed also can’t be made to work, but I suggest one final possibility that relies on a conventionalist metaphysics. -/- Chapter 5 is where I develop an account of conventionalist neutral monism and explain how it avoids the common dilemma raised against Russellian monism. Here I show how a conventionalist neutral monism is both coherent and substantially different from the other solutions to the mind-body problem. -/- Chapter 6 relates the solution developed in Chapter 5 to the question raised at the beginning of the dissertation and shows how a conventionalist neutral monist ought to answer the question. This answer does two things. First, it helps explain what goes wrong with the standard understanding of the Causal Argument and the Epistemic Argument that creates the appearance of an impasse. Second, it shows how conventionalist neutral monism successfully meets the demands developed in Chapter 1. (shrink)

Hans Reichenbach’s pragmatic treatment of the problem of induction in his later works on inductive inference was, and still is, of great interest. However, it has been dismissed as a pseudo-solution and it has been regarded as problematically obscure. This is, in large part, due to the difficulty in understanding exactly what Reichenbach’s solution is supposed to amount to, especially as it appears to offer no response to the inductive skeptic. For entirely different reasons, the significance of Bertrand Russell’s (...) classic attempt to solve Hume’s problem is also both obscure and controversial. Russell accepted that Hume’s reasoning about induction was basically correct, but he argued that given the centrality of induction in our cognitive endeavors something must be wrong with Hume’s basic assumptions. What Russell effectively identified as Hume’s (and Reichenbach’s) failure was the commitment to a purely extensional empiricism. So, Russell’s solution to the problem of induction was to concede extensional empiricism and to accept that induction is grounded by accepting both a robust essentialism and a form of rationalism that allowed for a priori knowledge of universals. So, neither of those doctrines is without its critics. On the one hand, Reichenbach’s solution faces the charges of obscurity and of offering no response to the inductive skeptic. On the other hand, Russell’s solution looks to be objectionably ad hoc absent some non-controversial and independent argument that the universals that are necessary to ground the uniformity of nature actually exist and are knowable. This particular charge is especially likely to arise from those inclined towards purely extensional forms of empiricism. In this paper the significance of Reichenbach’s solution to the problem of induction will be made clearer via the comparison of these two historically important views about the problem of induction. The modest but important contention that will be made here is that the comparison of Reichenbach’s and Russell’s solutions calls attention to the opposition between extensional and intensional metaphysical presuppositions in the context of attempts to solve the problem of induction. It will be show that, in effect, what Reichenbach does is to establish an important epistemic limitation of extensional empiricism. So, it will be argued here that there is nothing really obscure about Reichenbach’s thoughts on induction at all. He was simply working out the limits of extensional empiricism with respect to inductive inference in opposition to the sort of metaphysics favored by Russell and like-minded thinkers. (shrink)

Michael McKenna’s Conversation and Responsibility is an ambitious and impressive statement of a new theory of moral responsibility. McKenna’s approach builds upon the strategy advanced in P.F. Strawson’s enormously influential “Freedom and Resentment” (which was published in 1962). The account advanced aims to provide Strawson’s theory with the sort of detail that is required to fill significant gaps and respond to a wide range of criticisms and objections that have been directed against it. ....Conversation and Responsibility belongs on the (...) top shelf of any set of readings devoted to the contemporary discussion of moral responsibility. All readers, whatever their philosophical orientation may be, will find it both challenging and rewarding. Whether in the end one endorses the conversational model or not, there can be no doubt that this is a contribution that significantly advances our overall understanding of these important and complex matters. (shrink)

What might film’s contribution be to the work of acknowledgment, apology, and moral repair? James Baldwin's 1976 book on film, The Devil Finds Work, can be read as a reflection on the role that film might play in the extensive, multi-dimensional, public task of, as he puts it, putting ourselves in touch with reality, specifically the reality of American racism as an integral to American reality, its past and present. Developing Baldwin's thought, this paper outlines two broad types of cinematic (...) pictures or conceptions of racism: (1) films can present racism as a special event, or (2) films can present racism as a pervasive, structural reality. The former is complicit in a racist ideology that pictures racism as exceptional, rare, and unusual; the latter functions to critique such an ideology by picturing racism, not as a departure from the norm, but as constitutive of it. I develop a formal account of these cinematic pictures or conceptions through close analysis of two films made three years apart: Norman Jewison’s 1967 In the Heat of the Night (which Baldwin also analyses) and Michael Roemer’s 1964 film Nothing But a Man. (shrink)

Allen Buchanan and Russel Powell’s The Evolution of Moral Progress (EMP) is likely to become a landmark. It adeptly builds on much of the recent empirical work, weaving it together with philosophical material drawn from a series of essays published by the two authors. EMP makes the case that moral progress is not only consistent with human psychology but—under some conditions—likely. At its heart is a careful, well-developed rebuttal to the idea that there are evolved constraints endogenous to human minds (...) that place significant limits on various forms of moral progress, especially on the spread and sustainability of inclusive values. The alternative picture they present acknowledges that evolutionary history has shaped how our minds produce behaviour, but emphasizes that the contexts in which they currently operate are just as pivotal. While safe and stable ecological and social circumstances are hospitable to cosmopolitanism and encouraging of inclusive values, dangerous and threatening circumstances are more favourable to parochialism, exclusivist values, and morally regressive outgroup hostility (also see Buchanan and Powell [2015], [2016], [2017]). Overall, EMP is a compelling, well-researched, and timely book. It articulates arguably the most persuasive naturalistic theory of moral progress to date, and lays the groundwork for important and impactful research. (shrink)

Numbers without Science opposes the Quine-Putnam indispensability argument, seeking to undermine the argument and reduce its profound influence. Philosophers rely on indispensability to justify mathematical knowledge using only empiricist epistemology. I argue that we need an independent account of our knowledge of mathematics. The indispensability argument, in broad form, consists of two premises. The major premise alleges that we are committed to mathematical objects if science requires them. The minor premise alleges that science in fact requires mathematical objects. The most (...) common rejection of the argument denies its minor premise by introducing scientific theories which do not refer to mathematical objects. Hartry Field has shown how we can reformulate some physical theories without mathematical commitments. I argue that Field’s preference for intrinsic explanation, which underlies his reformulation, is ill-motivated, and that his resultant fictionalism suffers unacceptable consequences. I attack the major premise instead. I argue that Quine provides a mistaken criterion for ontic commitment. Our uses of mathematics in scientific theory are instrumental and do not commit us to mathematical objects. Furthermore, even if we accept Quine’s criterion for ontic commitment, the indispensability argument justifies only an anemic version of mathematics, and does not yield traditional mathematical objects. The first two chapters of the dissertation develop these results for Quine’s indispensability argument. In the third chapter, I apply my findings to other contemporary indispensabilists, specifically the structuralists Michael Resnik and Stewart Shapiro. In the fourth chapter, I show that indispensability arguments which do not rely on Quine’s holism, like that of Putnam, are even less successful. Also in Chapter 4, I show how Putnam’s work in the philosophy of mathematics is unified around the indispensability argument. In the last chapter of the dissertation, I conclude that we need an account of mathematical knowledge which does not appeal to empirical science and which does not succumb to mysticism and speculation. Briefly, my strategy is to argue that any defensible solution to the demarcation problem of separating good scientific theories from bad ones will find mathematics to be good, if not empirical, science. (shrink)

nated discussion of the semantics of such verbs. I will call this view.

The distinction between the force/mode of speech acts and intentional states and their propositional content has been a central feature of analytic philosophy since Gottlob Frege and Bertrand Russell. In this introduction we present the distinction and its motivation and review some recent challenges to it that appeal to the problem of the unity of the proposition, in order to give the reader a sense of the current state of debate to which the contributions of this volume respond.

According to a prevalent view among philosophers formal logic is the philosopher’s main tool to assess the validity of arguments, i.e. the philosopher’s ars iudicandi. By drawing on a famous dispute between Russell and Strawson over the validity of a certain kind of argument – of arguments whose premises feature definite descriptions – this paper casts doubt on the accuracy of the ars iudicandi conception. Rather than settling the question whether the contentious arguments are valid or not, Russell (...) and Strawson, upon discussing the proper logical analysis of definite descriptions, merely contrast converse informal validity assessments rendered explicit by nonequivalent logical for-malizations. (shrink)

Although now over 25 years old, many of the essays are quite contemporary. As expected, none of the authors grasp the full relevance of W for the description of behavior, missing most of the points made in my comments above, his many examples of how S1becomes S2, his role as a pioneer in EP, and his attempts to separate nature from nurture. Brose has many good points and is aware of the foundational nature of On Certainty, but is too scattered (...) and does not clearly describe W’s analysis of how our innate automatic unconscious S1 is the axiomatic basis for all behavior (but with a few exceptions nobody else to this day has either). Russell’s article is excellent, especially the first part dealing with Kripke’s famously distorted view of W. For a more recent and superb deconstruction of Kripke’s W that is of very general application, see “Kripke’s conjuring Trick” by Read and Sharrock, available on the net. I also found Coulter’s article quite good and like Margolis and Harre, he has continued his work to the present day and published widely. Margolis is very bright and well read but his precious prose and attempt to include as many references as possible results in a lack of clarity and focus. Rosch makes the best effort to apply W to real research but also lacks the broad understanding of him that could transform the view of higher order thought. Harre has since become a major W scholar but has little to say here, so those interested should see my review of his “Wittgenstein and Psychology”. Overall, considering that this book was written over 25 years ago and most of the authors were not philosophers they did a good job and the volume is still worth reading. -/- Those wishing a comprehensive up to date account of Wittgenstein, Searle and their analysis of behavior from the modern two systems view may consult my article The Logical Structure of Philosophy, Psychology, Mind and Language as Revealed in Wittgenstein and Searle (2016). Those interested in all my writings in their most recent versions may download from this site my e-book ‘Philosophy, Human Nature and the Collapse of Civilization Michael Starks (2016)- Articles and Reviews 2006-2016’ by Michael Starks First Ed. 662p (2016). -/- All of my papers and books have now been published in revised versions both in ebooks and in printed books. -/- Talking Monkeys: Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B071HVC7YP. -/- The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle--Articles and Reviews 2006-2016 (2017) https://www.amazon.com/dp/B071P1RP1B. -/- Suicidal Utopian Delusions in the 21st century: Philosophy, Human Nature and the Collapse of Civilization - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B0711R5LGX . (shrink)

Are science and religion compatible when it comes to understanding cosmology (the origin of the universe), biology (the origin of life and of the human species), ethics, and the human mind (minds, brains, souls, and free will)? Do science and religion occupy non-overlapping magisteria? Is Intelligent Design a scientific theory? How do the various faith traditions view the relationship between science and religion? What, if any, are the limits of scientific explanation? What are the most important open questions, problems, or (...) challenges confronting the relationship between science and religion, and what are the prospects for progress? These and other questions are explored in Science and Religion: 5 Questions--a collection of thirty-three interviews based on 5 questions presented to some of the world's most influential and prominent philosophers, scientists, theologians, apologists, and atheists. Contributions by Simon Blackburn, Susan Blackmore, Sean Carroll, William Lane Craig, William Dembski, Daniel C. Dennett, George F.R. Ellis, Owen Flanagan, Owen Gingerich, Rebecca Newberger Goldstein, John F. Haught, Muzaffar Iqbal, Lawrence Krauss, Colin McGinn, Alister McGrath, Mary Midgley, Seyyed Hossein Nasr, Timothy O'Connor, Massimo Pigliucci, John Polkinghorne, James Randi, Alex Rosenberg, Michael Ruse, Robert John Russell, John Searle, Michael Shermer, Victor J. Stenger, Robert Thurman, Michael Tooley, Charles Townes, Peter van Inwagen, Keith Ward, Rabbi David Wolpe. (shrink)

Easy to understand philosophy papers in all areas. Table of contents: Three Short Philosophy Papers on Human Freedom The Paradox of Religions Institutions Different Perspectives on Religious Belief: O’Reilly v. Dawkins. v. James v. Clifford Schopenhauer on Suicide Schopenhauer’s Fractal Conception of Reality Theodore Roszak’s Views on Bicameral Consciousness Philosophy Exam Questions and Answers Locke, Aristotle and Kant on Virtue Logic Lecture for Erika Kant’s Ethics Van Cleve on Epistemic Circularity Plato’s Theory of Forms Can we trust our senses? Yes (...) we can Descartes on What He Believes Himself to Be The Role of Values in Science Modern Science Kant’s Moral Philosophy Plato’s Republic as Pol Potist Bureaucracy Schopenhauer on Human Suffering Bertrand Russell on the Value of Philosophy The Philosophical Value of Uncertainty Logic Homework: Theorems and Models Searle vs. Turing on the Imitation Game Hume, Frankfurt, and Holbach on Personal Freedom Manifesto of the University of Wisconsin, Madison Secular Society Michael’s Analysis of the Limits of Civil Protections Bentham and Mill on Different Types of Pleasure Set Theory Homework Aristotle on Virtue Nagel On the Hard Problem Wittgenstein on Language and Thought Camus and Schopenhauer on the Meaning of Life Camus’ Hero as Rebel without a Cause My Little Finger: Camus’ Absurdism Illustrated Are Late-term Abortions Ethical? Does Mathematics Assume the Truth of Platonism? The Self-defeating Nature of Utilitarianism and Consequentialism Generally What is The Good Life? Bentham and Mill regarding types of pleasures Kant’s Moral Philosophy Five Short Papers on Mind-body Dualism Tracy Latimer’s Father had the Right to Kill Her: Towards a doctrine of generalized self-defense Arguments Concerning God and Morality Goldman, Rousseau and von Hayek on the Ideal State J.S Mill on Liberty and Personal Freedom A Kantian Analysis of a Borderline Date-rape Situation Living Well as Flourishing: Aristotle’s Conception of the Good Life Three Essays on Medical Ethics: Answers to Exam Questions on Elective Amputation, Vaccination, and Informed Consent Hobbes, Marx, Rousseau, Nietzsche: Their Central Themes De Tocqueville on Egoism Mill vs. Hobbes on Liberty Exam-Essays on the Moral Systems of Mill, Bentham, and Kant Kant’s Moral System Aristotle on Virtue Plato’s Cave Allegory An Ethical Quandary Superorganisms The Tuskegee Experiment A Rawlsian Analysis Why Moore’s Proof of an External World Fails A Defense of Nagel’s Argument Against Materialism A Utilitarian Analysis of a Case of Theft The Paradox of the Self-aware Wretch: An Analysis of Pascal’s Moral Philosophy Jean-Paul Sartre: Decline and Fall of a Marxist Sell-out A One Page Proof of Plato’s Theory of Forms Plato’s Republic as Pol Potist Bureaucracy The problem of the one and the many Four Short Essays on Truth and Knowledge What is ‘the Good Life?’ The Ontological Argument Different Political Philosophies: Plato, Locke, Madison, Rousseau, Hayek, and Mill on the State What do I know with certainty? Skepticism about skepticism Neuroscience and Freewill Operant Conditioning What makes us special? Are Late-term Abortions Ethical? No Two Papers on Epistemology: Gettier and Bostrom Examination Nietzsche on Punishment God’s Foreknowledge and Moral Responsibility . (shrink)

Although now over 25 years old, many of the essays are quite contemporary. As expected, none of the authors grasp the full relevance of W for the description of behavior, missing most of the points made in my comments above, his many examples of how S1 becomes S2, his role as a pioneer in EP, and his attempts to separate nature from nurture. Brose has many good points and is aware of the foundational nature of On Certainty, but is too (...) scattered and does not clearly describe W’s analysis of how our innate automatic unconscious S1 is the axiomatic basis for all behavior (but with a few exceptions nobody else to this day has either). Russell’s article is excellent, especially the first part dealing with Kripke’s famously distorted view of W. For a more recent and superb deconstruction of Kripke’s W that is of very general application, see ‘Kripke’s conjuring Trick’ by Read and Sharrock. I also found Coulter’s article quite good, and like Margolis and Harre, he has continued his work to the present day and published widely. Margolis is very bright and well-read but his precious prose and attempt to include as many references as possible results in a lack of clarity and focus. Rosch makes the best effort to apply W to real research but also lacks the broad understanding of him that could transform his view of higher order thought. Harre has since become a major W scholar but has little to say here, so those interested should see my review of his ‘Wittgenstein and Psychology’. Overall, considering that this book was written over 25 years ago, and most of the authors were not philosophers, they did a good job and the volume is still worth reading. -/- Those wishing a comprehensive up to date framework for human behavior from the modern two systems view may consult my book ‘The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle’ 2nd ed (2019). Those interested in more of my writings may see ‘Talking Monkeys--Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet--Articles and Reviews 2006-2019 3rd ed (2019), The Logical Structure of Human Behavior (2019), and Suicidal Utopian Delusions in the 21st Century 4th ed (2019) . (shrink)

This paper shows that Russell’s theory of descriptions gives the wrong se-mantics for definite descriptions occurring in questions and imperatives. Depending on how that theory is applied, it either assigns nonsense to per-fectly meaningful questions and assertions or it assigns meanings that di-verge from the actual semantics of such sentences, even after all pragmatic and contextual variables are allowed for. Given that Russell’s theory is wrong for questions and assertions, it must be wrong for assertoric state-ments; for the (...) semantics of ‘the phi’ obviously doesn’t vary depending on whether it occurs in a question or an assertion or a command. (shrink)

A collection of articles on the the principles of social justice from an Australian Catholic perspective. Contents: Forward (Archbishop Philip Wilson), Introduction (James Franklin), The right to life (James Franklin), The right to serve and worship God in public and private (John Sharpe), The right to religious formation (Richard Rymarz), The right to personal liberty under just law (Michael Casey), The right to equal protection of just law regardless of sex, nationality, colour or creed (Sam Gregg), The right to (...) freedom of expression (Damian Grace), The right to choose and freely maintain a state of life, married or single, lay or religious (Marita Winters), The right to education (Anthony Cleary), The right to petition government for the redress of grievances (Paul Russell), The right to a nationality (Andrew Hamilton), The right to have access to the means of livelihood, by migration when necessary (Brenda Hubber), The right of association and peaceful assembly (Michael Hogan), The right to work and choose one's occupation (Ian Blandthorn), The right to personal ownership, use and disposal of property subject to the right of others (Brian Coman), The right to a living wage (Garrick Small), The right to collective bargaining (Keith Harvey), The right to associate by industries and professions to obtain economic justice (Henrik Jurisevic), The right to assistance from society, if necessary from the State, in distress of persons and family (Catherine Althaus), Afterword (James Franklin). (shrink)

In order to understand a sentence, one must know the relevant semantic rules. Those rules are not learned in a vacuum; they are given to one through one's senses. As a result, knowledge of semantic rules sometimes comes bundled with semantically irrelevant, but cognitively non-innocuous, knowledge of the circumstances in which those rules were learned. Thus, one must work through non-semantic information in order to know what is literally meant by a given sentence-token. A consequence is that one's knowledge of (...) what is literally meant by a given sentence-token is sometimes embedded in non-semantic knowledge, resulting in a cleavage between what that sentence-token literally means and what the auditor in question takes it to mean. Such deviations obviously have nothing to do with the principles put forth by Grice, since those principles only concern sentence-tokens that have already been understood---since, to put it another way, those principles only concern post-semantic implicature. The just-described deviations are appropriately described as being due to "pre-semantic implicature." Given the phenomenon of pre-semantic implicature, it is easily shown that Russell's Theory of Descriptions, if taken as a theory of literal meaning, is false. In the present volume, these rather elementary principles are entirely ignored, and all of the articles in it are sterile repetitions of the points made by Russell and Strawson. The blinkered approach to language embodied in this volume must be reconsidered in light of psychological principles relating to language-acquisition and language-use. Unfortunately, analytic philosophers shy away from such topics, as is made clear by the papers in this grim volume. (shrink)

Providing the most thorough coverage available in one volume, this comprehensive, broadly based collection offers a wide variety of selections in four major genres, and also includes a section on film. Each of the five sections contains a detailed critical introduction to each form, brief biographies of the authors, and a clear, concise editorial apparatus. Updated and revised throughout, the new Fourth Edition adds essays by Margaret Mead, Russell Baker, Joan Didion, Annie Dillard, and Alice Walker; fiction by Nathaniel (...) Hawthorne, Ursula K. LeGuin, Anton Chekov, James Joyce, Katherine Mansfield, F. Scott Fitzgerald, William Faulkner, Alice Walker, Louise Erdrich, Donald Barthelme, and James McPherson; poems by John Donne, Robert Browning, Walt Whitman, Edwin Arlington Robinson, e.e. cummings, Langston Hughes, W.H. Auden, Philip Levine, and Louise Gluck; and plays by August Wilson, Marsha Norman, Wendy Wasserstein, and Vaclav Havel. The chapter devoted to film examines the relation of film to literature and gives the complete screenplay for Citizen Kane plus close analysis of a scene from the film. With its innovative structure, comprehensive coverage, and insightful and stimulating presentation of all kinds of literature, this is an anthology readers will turn to again and again. (shrink)

Russell corresponded with Sir Michael Dummett (1925–2011) between 1953 and 1963 while the latter was working on a book on Frege, eventually published as Frege: Philosophy of Language (1973). In their letters they discuss Russell’s correspondence with Frege, translating it into English, as well as Frege’s attempted solution to Russell’s paradox in the appendix to vol. 2 of his Grundgesetze der Arithmetik. After Dummett visited the University of Münster to view Frege’s Nachlaß, he sent reports back (...) to Russell concerning both the philosophical materials Frege left behind, as well as information from Frege’s journal revealing his anti-semitic political opinions. Their interaction contains interpretive conjectures and insights on Dummett’s side, and some dark humor on Russell’s. (shrink)

The Introduction to "Knowledge, Number and Reality. Encounters with the Work of Keith Hossack" provides an overview over Hossack's work and the contributions to the volume.

This collection of essays by acclaimed philosophers explores Bertrand Russell's influence on one of the dominant philosophical approaches of this century. Michael Dummett argues that analytical philosophy began with Gottlob Frege's analysis of numbers. Frege had begun by inquiring about the nature of number, but found it more fruitful to ask instead about the meanings of sentences containing number words. Russell was to exploit this method systematically. I reflect on the essays of Charles R. Pigden, David Lewis (...) as an exponent of a variant of Russell's position: the good is what we are ideally disposed to desire to desire, and Greenspan's suggestion that Russell adopted some element of the Marxist theory on morals. (shrink)

Keith Donnellan wrote his paper on definite descriptions in 1966 at Cornell University, an environment where nearly everybody was discussing Wittgenstein’s ideas of meaning as use. However, his idea of different uses of definite descriptions became one of the fundamental tenets against descriptivism, which was considered one of the main legacies of the Frege–Russell– Wittgenstein view; and I wonder whether a more Wittgensteinian interpretation of Donnellan’s work is possible.

Taking my cue from Michael Smith, I try to extract a decent argument for non-cognitivism from the text of the Treatise. I argue that the premises are false and that the whole thing rests on a petitio principi. I then re-jig the argument so as to support that conclusion that Hume actually believed (namely that an action is virtuous if it would excite the approbation of a suitably qualified spectator). This argument too rests on false premises and a begged (...) question. Thus the Motivation Argument fails BOTH as an argument for noncognitivism AND as an argument for what Hume actually believed, that moral distinctions are not derived from reason and that moral properties are akin to secondary qualities. So far as the Motivation Argument is concerned, both cognitivists and rationalists can rest easy. Themes: 1) Hume’s Slavery of Reason thesis is only defensible if passions are not only desires but sometimes dispositions to acquire desires (DTADs). 2) A desire for our good on the whole, which Humeans need to posit to fend off apparent counterexamples to the Slavery of Reason Thesis, does not sit well with the Humean theory of how novel desires arise (an objection due originally to Reid). 3) Hume is wrong to suppose that ‘abstract or demonstrative reasoning never influences any of our actions, but only as it directs our judgment concerning causes and effects’ as the examples of Russell and Hobbes convincingly demonstrate. This ironic as both Russell and Hobbes subscribed to the Slavery of Reason Thesis. 4) I critique Michael Smith’s critique of motivational externalism. (shrink)

Michael Tye’s book has two main themes: (i) the rejection of the ‘phenomenal concept strategy’ as a solution to the problems of consciousness for physicalism, and (ii) a new proposed solution to these problems which appeals to Russell’s (1910–11) distinction between knowledge by acquaintance and knowledge by description. Interweaved between these two main themes are a number of radical new claims about perceptual consciousness, including a defence of a sort of disjunctivism about perceptual content and an interesting account (...) of the phenomena of change blindness and inattentional blindness. Tye’s book shows all his usual philosophical virtues: it is bold, clear, inventive, and demonstrates his admirable willingness to scrutinise critically his earlier views. (shrink)

Around 1970, both Keith Donnellan and Saul Kripke produced powerful arguments against description theories of proper names. They also offered sketches of positive accounts of proper name reference, highlighting the crucial role played by historical facts that might be unknown to the speaker. Building on these sketches, in the following years Michael Devitt elaborated his well-known causal theory of proper names. As I have argued elsewhere, however, contrary to what is commonly assumed, Donnellan’s and Kripke’s sketches point in (...) two rather different directions, by appealing to historical or causal facts of different sorts. In this paper, I shall discuss and criticize Devitt’s causal theory, which confuses things, I shall argue, by mixing, so to speak, Donnellan’s and Kripke’s sketches. (shrink)

Ontological functionalism's defining tenet is that mental properties can be defined wholly in terms of the general pattern of interaction of ontologically prior realizations. Ideological functionalism's defining tenet is that mental properties can only be defined nonreductively, in terms of the general pattern of their interaction with one another. My Self-consciousness Argument establishes: ontological functionalism is mistaken because its proposed definitions wrongly admit realizations into the contents of self-consciousness; ideological functionalism is the only viable alternative for functionalists. Michael Tooley's (...) critique misses the target: he offers no criticism of - except for an incidental, and incorrect, attack on certain self-intimation principles - and, since he himself proposes a certain form of nonreductive definition, he tacitly accepts. Finally, as with all other nonreductive definitions, Tooley's proposal can be shown to undermine functionalism's ultimate goal: its celebrated materialist solution to the Mind-Body Problem. The explanation of these points will require a discussion of: Frege-Russell disagreements regarding intensional contexts; the relationship between self-consciousness and the traditional doctrine of acquaintance; the role of self-intimation principles in functionalist psychology; and the Kripke-Lewis controversy over the nature of theoretical terms. (shrink)

It is fairly widely accepted that Saul Kripke, Keith Donnellan, and others showed in the 1960s–1980s that proper names, in particular uses by speakers, can refer to things free of anything like the epistemic requirements posited by Gottlob Frege and Bertrand Russell. This paper separates two aspects of the Frege–Russell view of name reference: the metaphysical thesis that names in particular uses refer to things in virtue of speakers thinking of those things and the epistemic thesis that (...) thinking of things requires a means of determining which thing one is thinking of. My question is whether the Kripke–Donnellan challenge should lead us to reject,, or both. Contrary to a popular line of thinking that sees practices or conventions, rather than singular thinking, as determinative of linguistic reference, my answer is that we should reject only the epistemic thesis, not the metaphysical one. (shrink)

In this paper I offer a defence of a Russellian analysis of the referential uses of incomplete (mis)descriptions, in a contextual setting. With regard to the debate between a unificationist and an ambiguity approach to the formal treatment of definite descriptions (introduction), I will support the former against the latter. In 1. I explain what I mean by "essentially" incomplete descriptions: incomplete descriptions are context dependent descriptions. In 2. I examine one of the best versions of the unificationist “explicit” approach (...) given by Buchanan and Ostertag. I then show that this proposal seems unable to treat the normal uses of misdescriptions. I then accept the challenge of treating misdescriptions as a key to solving the problem of context dependent descriptions. In 3. I briefly discuss Michael Devitt’s and Joseph Almog’s treatments of referential descriptions, showing that they find it difficult to explain misdescriptions. In 4. I suggest an alternative approach to DD as contextuals, under a normative epistemic stance. Definite descriptions express (i) what a speaker should have in mind in using certain words in a certain context and (ii) what a normal speaker is justified in saying in a context, given a common basic knowledge of the lexicon. In 5. I define a procedure running on contextual parameters (partiality, perspective and approximation) as a means of representing the role of pragmatics as a filter for semantic interpretation. In 6. I defend my procedural approach against possible objections concerning the problem of the boundaries between semantics and pragmatics, relying on the distinction between semantics and theory of meaning. (shrink)

This is a story about three of my favorite philosophers—Donnellan, Russell, and Frege—about how Donnellan’s concept of having in mind relates to ideas of the others, and especially about an aspect of Donnellan’s concept that has been insufficiently discussed: how this epistemic state can be transmitted from one person to another.

DESENVOLVIMENTO EMBRIONÁRIO E DIFERENCIAÇÃO SEXUAL -/- E. I. C. da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim Departamento de Zootecnia – UFRPE sede -/- 1.1 INTRODUÇÃO O sexo foi definido como a soma das diferenças morfológicas, fisiológicas e psicológicas que distinguem o macho da fêmea permitindo a reprodução sexual e assegurando a continuidade das espécies. Os processos de diferenciação sexual são realizados durante o desenvolvimento embrionário, onde ocorre a proliferação, diferenciação e maturação das células germinativas e primordiais, precursoras (...) de ovócitos e espermatozoides em fêmeas e machos, respectivamente. Assim, os embriões machos e fêmeas iniciam o seu desenvolvimento de forma semelhante, de modo que em ambos os sexos se estabelecem em estruturas idênticas a partir das quais se formarão os órgãos reprodutores correspondentes a cada sexo. O conhecimento da origem e do desenvolvimento do aparelho genital é indispensável para entender sua função e as alterações que produzem infertilidade ou esterilidade. 1.2 DETERMINAÇÃO DO SEXO CROMOSSÔMICO Nos mamíferos, o sexo cromossômico é determinado no momento da fertilização, quando um óvulo, que contém um cromossomo X, é fecundado por um espermatozoide portador de um cromossomo X ou um cromossomo Y. No primeiro caso, o complemento cromossômico seria XX, o que originaria uma fêmea (sexo homogamético), e no segundo daria como resultado um macho com a fórmula cromossômica XY (sexo heterogâmico). 1.3 A GÔNADA INDIFERENCIADA A primeira manifestação das gônadas se aprecia no embrião em forma de um par de eminências longitudinais chamadas cristas ou dobras gonodais, situadas em ambos os lados da linha média entre os mesonefros (rins em desenvolvimento) e do mesentério dorsal. Nos embriões dos mamíferos, as células germinativas primordiais (CGP) manifestam-se em estágios precoces do desenvolvimento, podendo ser detectadas pela primeira vez na metade da gastrulação. As CGP são células grandes, de citoplasma claro e núcleo grande e redondo, localizadas na parede do saco vitelino, perto do alantoide. Essas células possuem grande capacidade de proliferação e vão migrar desde o endoderma do intestino e o epitélio do saco vitelino, através do mesentério, até as cristas gonodais. Isso ocorre por volta do 26° dia da gestação no bovino. Sua migração realiza-se graças aos movimentos de translocação passiva e deslocamento ameboide ativo. Desconhece-se o mecanismo pelo qual estas células são dirigidas para as cristas gonodais, porém foram estudadas algumas moléculas que se expressam durante sua migração e que poderiam desempenhar um papel importante na diferenciação deste tipo celular. A fosfatase alcalina é uma enzima que tem sido usada como marcador de CGP para determinar a sua origem e migração. Num estudo recente, foi inserido um marcador fluorescente que se exprime unicamente nas células germinativas primordiais de embriões transgênicos, e utilizando este marcador e a fosfatase alcalina determinou-se a origem e o padrão de migração destas células. O primeiro sinal de diferenciação das células germinativas primordiais é a expressão de fosfatase alcalina, e esta apareceu pela primeira vez na parte mais posterior da linha primitiva. No sétimo dia de desenvolvimento no embrião do camundongo, o endoderma visceral (AF+) é substituído pelo endoderma definitivo (AF-) originado na parte anterior da linha primitiva. O fator de transcrição Oct-4 é expresso nas CGP de ambos os sexos, pelo que acredita-se estar envolvido na mantença a totipotêncialidade das células. O receptor tirosina quinase, cujo ligante é o fator de Steel, é outra das moléculas que expressam as CGP. Tem sido demonstrado que este receptor possui um papel muito importante na sobrevivência deste tipo celular. Existem outros fatores que promovem a sobrevivência e/ou proliferação de CGP in vitro. Em experiências realizadas com o fator de transformação beta I (TGFβ-I), observou-se que este tem um efeito negativo sobre a proliferação das CGP. Outra atividade que tem sido postulada a este fator é o de um agente quimioatraente que possivelmente possa direcionar a migração destas células para a gônada. a) Um formado pelas células germinativas primordiais (precursoras dos gametas masculinos ou femininos), rodeadas de células somáticas das quais posteriormente se derivarão as células de Sertoli no macho e as células da granulosa na fêmea. b) O tecido que formará o estroma da gônada: tecido conjuntivo, vasos sanguíneos e as células intersticiais com atividade esteroidogênica (células de Leydig no testículo e a teca interna do ovário). As células somáticas do primórdio gonodal originam-se do mesoderma. Inicialmente são de três tipos: mesenquimáticas, mesoteliais e endoteliais. As células mesenquimáticas e mesoteliais iniciam grande atividade proliferativa ao chegar as CGP. Observa-se então uma condensação de células de origem mesotelial e mesenquimatoso que forma um agregado compacto denominado "blastema gonodal". A partir deste primórdio embrionário, diferenciam-se dois tecidos gonodais: os cordões sexuais e o estroma. Os cordões sexuais são arranjos epiteliais que se encontram delimitados por uma folha basal, e dentro deles encontramos as CGP. Por sua vez, no estroma encontram-se células do tipo mesenquimático e vasos sanguíneos. Neste momento, as gônadas são indiferenciadas e bipotencialmente sexuais, sendo impossível diferenciar, morfologicamente, uma gônada masculina de uma feminina, mas no caso dos machos genéticos já existe uma diferenciação da gônada a nível molecular. Nesta fase já se encontram presentes as estruturas das quais se desenvolvem os dutos mesonéfricos ou de Wolff precursores do aparelho genital masculino e os dutos paramesonéfricos ou de Müller que darão origem ao aparelho reprodutor feminino. Há uma série de fatores envolvidos no desenvolvimento precoce da gônada, entre os quais o fator esteroidogênico I (SFI: Steroidogenic fator l), que é um membro da subfamília de receptores nucleares, receptores órfãos. Este fator de transcrição tem um local de ligação ao DNA composto por dois dedos-de-Zinc. O SFI foi identificado como um ativador de genes envolvidos na biossíntese de esteroides em diferentes células. O SFI está presente durante o desenvolvimento embrionário em regiões associadas com funções endócrinas como gônadas, adrenais, pituitárias e hipotálamos. Os animais homozigotos para o gene SFI defeituoso, necessitam de gônadas e adrenais e têm a função gonadotrófica alterada. Os ratos sem SFI carecem de gonadotrofos e têm um desenvolvimento anormal do núcleo ventro-medial do hipotálamo; em particular as gônadas deixam de se desenvolver entre os dias 11 a 15 e degeneram-se por apoptose. No entanto, a crista genital forma-se e é colonizada pelas células germinativas, o que indica que estas continuam a receber o sinal adequado para a sua migração. Portanto, o SFI não está envolvido no desenvolvimento precoce da gônada e do sistema urogenital, mas parece estar envolvido na manutenção do crescimento das células somáticas presentes na gônada indiferenciada. O gene associado ao tumor de Wilms (WTI: Wilm's tumor Associated) está envolvido no desenvolvimento da gônada e do rim. Durante o desenvolvimento embrionário, WTI se expressa em todo o mesoderma intermediário e posteriormente na gônada indiferenciada, bem como no rim em formação. WTI regula o sinal indutivo do mesênquima para o epitélio celômico dos mesonefros. Se este for o caso, então WTI é responsável pelo crescimento da crista genital ao dirigir a entrada do epitélio celômico. Dado que estas células darão origem às células de Sertoli, a carência de WTI pode causar o desenvolvimento de embriões XY como fêmeas simplesmente porque não se formam as células de Sertoli. Em geral, todos os genes importantes na diferenciação do mesoderma intermediário e do sistema urogenital intervêm no desenvolvimento da gônada precoce. 1.4 DIFERENCIAÇÃO GONODAL O desenvolvimento das gônadas e ductos genitais descritos até o momento, é o mesmo para ambos os sexos. Igualmente, os genes descritos, que estão envolvidos no desenvolvimento das gônadas, ductos genitais e migração das células germinativas, afetam igualmente os embriões com genótipo XX ou XY. A gônada primitiva consiste anatomicamente de uma medula (interna) e uma crosta (externa), e de acordo com o local onde ocorre a colonização das células germinativas, diferenciara em testículo ou um ovário, respectivamente. Nos mamíferos, a primeira manifestação estrutural de diferenciação sexual é detectada na gônada dos machos, onde as células germinativas estão localizadas na medula. A diferenciação do testículo inicia-se quando os cordões sexuais se separam do epitélio celômico como consequência dos arranjos produzidos por uma invasão do mesênquima e vasos sanguíneos que provoca a compactação dos cordões, agora denominados cordões testiculares. As células que rodeiam os cordões se achatam e formam as células mioides, que são responsáveis pela formação das membranas basais. As células do epitélio interno, ou seja, as células de Sertoli, têm duas funções principais: o suporte das CGP e a síntese da hormona antimulleriana, responsável pela regressão dos ductos de Müller e secretada durante o período de diferenciação sexual. As células do estroma que rodeiam os cordões testiculares diferenciam-se para formar vários tipos de células: células mioides, fibroblastos, endotélio e células de Leydig, que são as mais importantes pela sua atividade endócrina. Posteriormente, os cordões testiculares dão origem aos túbulos seminíferos, que contêm o epitélio que produzirá os espermatozoides ao chegar à puberdade. Na fêmea, durante os estágios iniciais de diferenciação gonodal, não se observam mudanças em relação à gônada indiferenciada, só pode-se observar um certo crescimento devido à proliferação de células somáticas e germinativas. As células germinativas iniciam um período de proliferação, que termina com o início da meiose. Iniciada a meiose, dá-se o processo de foliculogênese; neste momento os cordões epiteliais se fragmentam, de tal maneira que cada ovócito fica rodeado de células epiteliais cobertas por uma folha basal fina (figura 1). Para que a gônada primitiva se desenvolva em testículo é indispensável a presença do cromossoma Y, independentemente do número de cromossomas X que contenha o genoma de um indivíduo. O gene determinante do testículo encontra-se localizado no cromossoma Y, denominado sry em ratos e SRY em humanos. O gene sry se expressa durante o desenvolvimento embrionário na crista genital de embriões de camundongos. A expressão é detectável no dia 10,5, pouco depois do aparecimento das cristas genitais, atinge o seu máximo durante o dia 11,5 e mantém-se até pouco depois de ocorrerem os primeiros sinais morfológicos de diferenciação testicular no dia 12,5. Este padrão de expressão é compatível com a teoria de que sry atua induzindo a ativação dos genes (figura 2) que conduzem ao desenvolvimento testicular, sem que exista a necessidade da expressão contínua de sry para manter a diferenciação do testículo após o dia 12,5. Como mencionado anteriormente, a gônada primitiva é composta por vários tipos de células. No entanto, as células germinativas primordiais não são o local de expressão do sry, já que os embriões que necessitam de células germinativas mantêm a expressão de sry e desenvolvem o sexo gonodal normalmente. As células somáticas na gônada em desenvolvimento incluem também as células de suporte. Sabe-se que é nestas células que o sry é expresso para que se diferenciem em células de Sertoli, e a expressão transitória de sry indica que deve ativar a outros genes para a manutenção das células de Sertoli. Uma vez diferenciadas as células de Sertoli, elas se encarregarão da diferenciação do resto das células na gônada. -/- Figura 1: Representação da diferenciação dos órgãos genitais internos. Adaptado de BRONSON, 1989. Figura 2: Cascada de genes envolvidos na diferenciação sexual, adaptado de KOOPMAN, 1999. O fator sry é necessário para a diferenciação do testículo. Embora não se conheçam os genes que provavelmente regulam esse gene, estudos realizados em camundongos demonstram que este gene parece coordenar-se com certos genes autossômicos. Entre estes genes autossômicos, o sox9, que é produzido pelas células de Sertoli uma vez que são estimuladas por sry, de modo que sox9 é um dos genes relacionados estruturalmente com sry. O Sox9 funciona como um fator de transcrição, mas não se sabe se a proteína tem qualquer outra função estrutural; este gene exprime-se abundantemente nos condrócitos e está relacionado com defeitos do aparelho ósseo chamados displasia campomélica. Curiosamente, os pacientes XY com esta condição sofrem frequentemente de reversão do sexo. O Sox9 é um dos poucos genes, além do SRY, do qual as mutações demonstraram interferir com a determinação sexual masculina. No entanto, apenas 75% dos pacientes com anomalias esqueléticas de tipo displasia campomélica têm reversão sexual e não foram encontrados casos de reversão sexual devido a um defeito de Sox9 que não seja acompanhado de defeitos esqueléticos. Isso indica que o Sox9 é apenas um membro da rede de genes que são ativados para determinar a diferenciação sexual, enquanto a rota que rege a condrogênese é mais sensível a perturbações deste. O momento em que se detecta a expressão do gene Sox9 (11dpc em ratos) coincide com a máxima expressão de sry, o que poderia indicar a possibilidade de que sry regule positivamente a Sox9. De fato, na região do promotor de Sox9 há um local de união ao que potencialmente se pode unir o sry. A expressão de Sox9 durante a diferenciação sexual sugere um papel abaixo de sry na diferenciação das células de Sertoli. O cromossoma X também é importante na diferenciação gonodal. O gene DAX-I foi isolado do lócus DSS (Dosage sensitive sex reversal) do cromossoma X. DAX-I é parte da cascata de determinação sexual, mas não é necessário para a formação do testículo. DAX-I é um membro dos receptores nucleares conhecidos como receptores órfãos. Este gene demonstrou ser um poderoso repressor da transcrição de SFI e de vários genes. Os padrões de expressão de DAX-I são complementares daqueles de SFI, ambos expressos nas cristas genitais. Em resumo, dada a evidência exposta, desenvolveu-se a hipótese de que DAX-I é um antagonista de sry; esse antagonismo é dependente dos níveis relativos de DAX-I e sry e de um limiar que varia de espécie para espécie. A DAX-I foi classificada como o gene antitestículo. Na fêmea (cariótipo XX) é importante que ocorra a inativação de um dos cromossomas sexuais X para que se mantenha o equilíbrio genético ao igualar o conteúdo de DNA dos cromossomas. Esse cromossoma inativado constitui o chamado corpúsculo de Barr. No entanto, para que a meiose se realize, é necessário dos dois cromossomas X ativos nos ovócitos para assegurar a diferenciação ovárica e a fertilidade. 1.5 DIFERENCIAÇÃO DOS DUCTOS SEXUAIS O embrião possui, além das gônadas indiferenciadas, dois sistemas de ductos: os de potencialidade masculina denominam-se ductos de Wolff ou mesonéfricos, e os de potencialidade feminina se chamam ductos de Müller ou paramesonéfricos (figura 1). Se a diferenciação gonodal levou à formação de um testículo, a partir do ducto mesonéfrico ou de Wolff se desenvolverão os ductos eferentes, o epidídimo, os ductos deferentes e as vesículas seminais. As hormonas importantes no desenvolvimento do aparelho genital masculino são a testosterona, produzida pelas células de Leydig, e sua forma 5α reduzida, a 5α di-hidrotestosterona. Acredita-se que a testosterona é responsável pela virilização dos ductos de Wolff, e a di-hidrotestosterona dos órgãos genitais externos. No macho, os canais de Müller atrofiam-se devido à ação de uma hormona fetal de origem testicular denominada hormona inibidora das estruturas de Müller (HIM) ou hormona antimulleriana. Este processo começa assim que os cordões espermáticos se formam e se diferenciam as células de Sertoli. A existência de HIM foi proposta baseada em estudos realizados em bezerras freemartin, devido à existência de uma hormona responsável pela atresia dos ductos de Müller que na fêmea dá origem ao útero e aos ovidutos. Essa hormona provoca a involução do aparelho genital do bovino nas gestações gemelares nas quais os produtos de diferente sexo têm comunicação sanguínea por ter ocorrido a anastomose dos vasos de ambas as placentas (figura 3). A HIM é uma glicoproteína pertencente à subfamília de TGFβ, é expressa pelas células que darão origem às células de Sertoli e é um dos primeiros marcadores de diferenciação nestas células. A HIM é secretada na vida adulta pelas células de Sertoli no testículo e por células da granulosa no ovário. No rato a HIM é expressa-se no 12° dia em um teste padrão que segue muito de perto o aumento na expressão de sry. No macho, esta secreção de HIM continua durante a vida fetal e adulta, contudo os níveis de HIM declinam na puberdade devido a um aumento na secreção de testosterona. Vários fatores intervêm na regulação do gene de HIM, incluindo os acima descritos SFI e Sox9. O gene HIM contém segmentos de DNA que são conservados em várias espécies de vertebrados. Existe um nexo de ligação para SFI, que ativa a transcrição de HIM. A mutação no local de ligação de SFI resulta em reversão do sexo em indivíduos XY incluindo genitais femininos normais, presença de um útero formado enfatizando a importância de SFI na determinação sexual e na expressão de HIM. Embora SFI seja um bom candidato como regulador de HIM, é expresso em outras células, como as de Leydig e adrenais, que não expressam HIM. Em contrapartida, Sox9 é expresso unicamente nas células de Sertoli que são as produtoras de HIM. O gene HIM também tem um nexo de ligação para Sox9. Além disso, Sox9 pode atuar sinergicamente com SFI para promover a secreção de HIM. Ao contrário destes dois fatores de transcrição, DAX-I antagoniza a ação de Sox9 e provavelmente SFI sobre o promotor de HIM. Assim, para que as células de Sertoli secretem HIM, a transcrição de DAX-I deve diminuir. Figura 3: Representação da diferenciação dos órgãos genitais externos. Adaptado de BRONSON, 1989. Os ductos de Wolff tornam-se o sistema de ejaculação do macho. A porção mais próxima dos testículos dá origem ao epidídimo, a parte central ao ducto deferente e a porção mais distal às vesículas seminais. A próstata e a parte membranosa da uretra do macho desenvolvem-se a partir da porção pélvica do seio urogenital. A virilização e diferenciação dos ductos de Wolff dependem da produção de testosterona pelo testículo. Quanto aos órgãos genitais externos do macho, o tubérculo genital é ampliado e as dobras uretrais se fundem para formar a uretra peniana. A fusão das dobras uretrais aproxima os tubérculos genitais para formar o escroto (figura 4). Figura 4: Diferenciação do aparelho genital da fêmea e do macho. Adaptado de KOOPMAN, 1989. A diferenciação dos órgãos genitais da fêmea ocorre de forma passiva, já que a ausência de testículos e por isso da hormona inibidora dos ductos de Müller (HIM), assim como dos andrógenos virilizantes, favorece o desenvolvimento dos ductos de Müller, enquanto os de Wolff sofrem atrofia. A porção cefálica dos ductos de Müller dá origem aos ovidutos, que na sua terminação caudal se fundem com o útero. O contato dos ductos de Müller com o seio urogenital induz uma intensa proliferação celular que resulta na formação da área uterovaginal localizado entre o seio urogenital e os ductos de Müller. As células do prato uterovaginal proliferam e aumentam a distância entre as duas estruturas criando o espaço que formará a vagina quando o prato é canalizado e forma um lúmen. Em contraste com o que ocorre no macho, na fêmea a maior parte do seio urogenital se mantém exposta na superfície da abertura onde desembocam a vagina e a uretra. O tubérculo urogenital da fêmea tem um crescimento limitado e forma o clitóris. A sequência de passos da diferenciação sexual do aparelho genital é resumida na tabela 1. Tabela 1: Destino em desenvolvimento dos rudimentos sexuais dos fetos macho e fêmea dos mamíferos -/- Rudimento sexual Macho Fêmea Gônada Testículo Ovário Ductos de Müller (Paramesonéfricos) Vestígios Útero, parte da vagina, ovidutos Ductos de Wolff (Mesonéfricos) Ductos eferentes deferentes, epidídimo, vesículas seminais Vestígios Seio urogenital Uretra, próstata, glândulas bulbouretrais Parte da vagina, uretra, vestíbulo, glândulas vestibulares Tubérculo genital Pênis Clitóris Pregas vestibulares Escroto Lábios vulvares Fonte: HAFEZ, 2004. 1.6 DIFERENCIAÇÃO SEXUAL DO HIPOTÁLAMO Os processos de diferenciação sexual não se limitam apenas às células somáticas do organismo do feto, mas incluem também os centros nervosos superiores do cérebro. Assim, da mesma maneira que a gônada e os ductos sexuais se desenvolvem para o tipo feminino ou masculino, propôs-se que o cérebro pode ser "masculinizado" ou permanecer "Feminizado". A diferenciação do hipotálamo vai depender do ambiente esteroidal do neonato e ocorre na fase perinatal. Estes eventos serão de grande transcendência na vida reprodutiva do indivíduo. Tanto a fêmea como o macho nascem com a capacidade de secreção de gonadotropinas de acordo com um padrão cíclico; contudo, no macho, a exposição do hipotálamo à ação dos andrógenos testiculares durante os primeiros dias da vida extrauterina provoca a masculinização, com o qual o hipotálamo do macho é programado para que a secreção de gonadotropinas se realize a um ritmo relativamente constante por parte da hipófise (secreção tônica). Na fêmea, tanto a secreção tônica como a cíclica se conservam. No entanto, observou-se que a injeção de testosterona ou o transplante de testículo na rata fêmea durante os primeiros dias de vida, suprime a sua futura atividade estral (secreção cíclica). Por outro lado, se os ovários forem transplantados para o rato macho normal castrado na idade adulta, o animal não desenvolve qualquer atividade cíclica, mas se os machos transplantados forem castrados ao nascer, o ovário é capaz de efetuar mudanças cíclicas e ovulações. Isto foi demonstrado em roedores, mas não em animais domésticos ou na espécie humana. Portanto, o padrão de secreção de gonadotropinas, seja cíclico ou tônico, não depende da hipófise, mas do hipotálamo e sua correta diferenciação. 1.7 CONCLUSÕES A maioria dos conhecimentos no campo da biologia do desenvolvimento e, muito especificamente, dos processos de diferenciação sexual têm sido originados de estudos relacionados com desordens congênitas, que na sua maioria devem-se a defeitos de genes específicos. A análise detalhada destas desordens permitiu entender alguns mecanismos endócrinos, moleculares e genéticos envolvidos na diferenciação sexual. A identificação do gene sry como determinante do testículo foi uma contribuição crucial e abriu as portas à compreensão dos mecanismos moleculares e celulares relacionados com o desenvolvimento do testículo. Se este gene não estiver presente, é criado um programa genético alternativo para levar a cabo a diferenciação gonodal para o ovário. Finalmente, devemos ter presente que é necessária uma correlação entre mudanças morfológicas e expressão de genes durante o desenvolvimento para entender os mecanismos relacionados com a diferenciação. -/- Apoio -/- Realização -/- REFERÊNCIAS BIBLIOGRÁFICAS ANDERSON, Robert et al. The onset of germ cell migration in the mouse embryo. Mechanisms of development, v. 91, n. 1-2, p. 61-68, 2000. AUSTIN, Colin Russell; SHORT, R. V. Reproduction in Mammals: Volume 1, Germ Cells and Fertilization. Londres: Cambridge University Press, 1972. BRONSON, Franklin H. Mammalian reproductive biology. Chicago: University of Chicago Press, 1989. BUEHR, Mia. The primordial germ cells of mammals: some current perspectives. Experimental cell research, v. 232, n. 2, p. 194-207, 1997. BYSKOV, Anne G. Differentiation of mammalian embryonic gonad. Physiological reviews, v. 66, n. 1, p. 71-117, 1986. CAPEL, Blanche et al. Migration of mesonephric cells into the mammalian gonad depends on Sry. Mechanisms of development, v. 84, n. 1-2, p. 127-131, 1999. CAPEL, Blanche. The battle of the sexes. Mechanisms of development, v. 92, n. 1, p. 89-103, 2000. DERIVAUX, Jules; BARNABÉ, Renato Campanarut. Reprodução dos animais domésticos. Zaragoza: Acribia, 1980. DOMENICE, Sorahia et al. Aspectos moleculares da determinação e diferenciação sexual. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 46, n. 4, p. 433-443, 2002. DONAHOE, Patricia K. et al. Mullerian inhibiting substance activity in bovine fetal, newborn and prepubertal testes. Biology of reproduction, v. 16, n. 2, p. 238-243, 1977. HAFEZ, Elsayed Saad Eldin; HAFEZ, B. Reprodução animal. São Paulo: Manole, 2004. HANLEY, Neil A. et al. Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. Molecular and cellular endocrinology, v. 163, n. 1-2, p. 27-32, 2000. HIORT, Olaf; PAUL-MARTIN, H. The molecular basis of male sexual differentiation. European journal of endocrinology, v. 142, n. 2, p. 101-110, 2000. HOLY, Lubos; MARTÍNEZ JÚSTIZ, G. Colab. Biología de la reproducción bovina. Havana: Revolucionária, 1975. JOSSO, Nathalie et al. The role of anti-Müllerian hormone in gonadal development. Molecular and cellular endocrinology, v. 145, n. 1-2, p. 3-7, 1998. JOST, Alfred et al. Studies on sex differentiation in mammals. In: Proceedings of the 1972 Laurentian Hormone Conference. Londres: Academic Press, 1973. p. 1-41. KNOBIL, Ernst. Knobil and Neill's physiology of reproduction. EUA: Gulf Professional Publishing, 2006. KOFMAN ALFARO, S.; MERCHANT LARIOS, H.; PEREZ PALACIOS, G. Diferenciacion sexual. I. Bases biologicas del dimorfismo sexual. Rev. invest. clín, p. 349-59, 1982. KOOPMAN, Peter. Sry and Sox9: mammalian testis-determining genes. Cellular and Molecular Life Sciences CMLS, v. 55, n. 6-7, p. 839-856, 1999. MCDONALD, L. E. Veterinary endocrinology. Lea & Febiger, Philadelphia, Pa, 1969. MEIZEL, S.; JOHNSON, M. H. Development in mammals. MH Johnson, Ed, v. 3, p. 1-64, 1978. MELLO, Maricilda Palandi de; ASSUMPÇÃO, Juliana de G.; HACKEL, Christine. Genes envolvidos na determinação e diferenciação do sexo. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 49, n. 1, p. 14-25, 2005. -/- REFERÊNCIAS BIBLIOGRÁFICAS MERCHANT-LARIOS, H. Ovarian differentiation. The Vertebrate Ovary, p. 47-81, 1978. MIES FILHO, Antonio. Reprodução dos animais. Porto Alegre: Sulina, 1987. NEF, Serge; PARADA, Luis F. Hormones in male sexual development. Genes & Development, v. 14, n. 24, p. 3075-3086, 2000. PARKER, Keith L.; SCHEDL, Andreas; SCHIMMER, Bernard P. Gene interactions in gonadal development. Annual review of physiology, v. 61, n. 1, p. 417-433, 1999. SWAIN, Amanda; LOVELL-BADGE, Robin. Mammalian sex determination: a molecular drama. Genes & development, v. 13, n. 7, p. 755-767, 1999. WILHELM, Dagmar; PALMER, Stephen; KOOPMAN, Peter. Sex determination and gonadal development in mammals. Physiological reviews, v. 87, n. 1, p. 1-28, 2007. WILSON, Jean D.; GRIFFIN, James E.; GEORGE, Fredrick W. Sexual differentiation: early hormone synthesis and action. Biology of reproduction, v. 22, n. 1, p. 9-17, 1980. -/- Emanuel Isaque Cordeiro da Silva Belo Jardim, 07 de Maio de 2020. (shrink)

In a previous issue of this journal, Michael Hicks challenges my critique of Wilfrid Sellars’s arguments against the given and against the foundationalist epistemology that relies on the idea of a sensory given. I had argued that Sellars’s well-known claim that the given is a myth does not succeed because at a critical juncture he misconstrued sense-datum theorists such as Bertrand Russell and H. H. Price. In his response to my argument, Hicks makes the striking claim that Sellars (...) was not targeting foundationalism at all in his discussion of the myth of the given. Hicks reconstructs a key argument in “Empiricism and the Philosophy of Mind” (EPM) in a way intended both to avoid any reference to foundationalism and to do a more effective job than does Sellars’s original argument in uncovering a dilemma for traditional empiricism. The present paper challenges Hicks on two fronts. First, it argues that Hicks’s reconstruction is not more successful than Sellars’s original argument. Second, a review of relevant passages in makes clear that the critique of foundationalism is a prominent aspect of Sellars’s multi-faceted attack on the given. The conclusion reasserts the significance of Sellars’s place in the history of twentieth-century analytic philosophy. (shrink)

In this paper I take a closer look at Bertrand Russell's ontology of facts, pro- posed in his 1918 lectures on "The Philosophy of Logical Atomism". Part II is devoted to the question what Russell considered facts to be, and what kinds of facts he assumed. In part III, the controversy over two kinds of facts Russell postulates is described; the opinions of Raphael Demos and Keith Halbasch are considered for this purpose. Following this discussion, part (...) IV investigates the question as to what kind of analysis Russell is conducting that leads him to negative and general facts. Finally, in part V, my conclusions drawn from the combined information of parts II to IV are elaborated; the main claim being, that due to the kind of analysis Russell is conducting, he is not making a mis- take when he assumes negative and general facts. (shrink)

Gottlob Frege abandoned his logicist program after Bertrand Russell had discovered that some assumptions of Frege’s system lead to contradiction (so called Russell’s paradox). Nevertheless, he proposed a new attempt for the foundations of mathematics in two last years of his life. According to this new program, the whole of mathematics is based on the geometrical source of knowledge. By the geometrical source of cognition Frege meant intuition which is the source of an infinite number of objects in (...) arithmetic. In this article, I describe this final attempt of Frege to provide the foundations of mathematics. Furthermore, I compare Frege’s views of intuition from The Foundations of Arithmetic (and his later views) with the Kantian conception of pure intuition as the source of geometrical axioms. In the conclusion of the essay, I examine some implications for the debate between Hans Sluga and Michael Dummett concerning the realistic and idealistic interpretations of Frege’s philosophy. (shrink)

There are infinitely many ways the world might be, and there may well be infinitely many people in it. These facts raise moral paradoxes. We explore a conflict between two highly attractive principles: a Pareto principle that says that what is better for everyone is better overall, and a statewise dominance principle that says that what is sure to turn out better is better on balance. We refine and generalize this paradox, showing that the problem is faced by many theories (...) of interpersonal aggregation besides utilitarianism, and by many decision theories besides expected value theory. Considering the range of consistent responses, we find all of them to be quite radical. (shrink)

Suppose that, for reasons of animal welfare, it would be better if everyone stopped eating chicken. Does it follow that you should stop eating chicken? Proponents of the “inefficacy objection” argue that, due to the scale and complexity of markets, the expected effects of your chicken purchases are negligible. So the expected effects of eating chicken do not make it wrong. -/- We argue that this objection does not succeed, in two steps. First, empirical data about chicken production tells us (...) that the expected effects of consuming *many* chickens are not negligible. Second, this implies that the expected effect of consuming one chicken is ordinarily not negligible. *Parity* between your purchase and other counterfactual purchases and *uncertainty* about others’ consumption behavior each tend to pull the expected effect of a single purchase toward the average large scale effect. While some purchases do have negligible expected effects, many do not. (shrink)

Provides a comprehensive overview and introduction to the Routledge Handbook of Propositions.

FISIOLOGIA DA REPRODUÇÃO BOVINA: 2 - ESTRO E SERVIÇO -/- -/- INTRODUÇÃO -/- -/- A identificação de vacas em cio (estro ou cio) é, sem dúvida, a prática mais importante no manejo da reprodução do rebanho leiteiro. Apesar dos avanços no conhecimento da fisiologia da reprodução a nível celular e molecular, a identificação de vacas em estro continua sendo o problema reprodutivo mais importante e o que mais causa prejuízos econômicos. Na indústria de laticínios no Brasil, seu impacto não foi (...) estimado, porém, a estimativa feita por países como os Estados Unidos onde se perdem 300 milhões de dólares por ano pode dar uma ideia, atribuída apenas à baixa eficiência na detecção de estros. Por que é cada vez mais difícil detectar vacas em estro? A resposta está relacionada aos aspectos intrínsecos da vaca leiteira moderna, associadas as práticas de manejo dos rebanhos atuais, caracterizados por possuírem grande número de vacas nos plantéis. -/- -/- 2.1 Como saber que uma vaca está em cio/estro? -/- -/- O comportamento estral é causado por um aumento no estradiol sérico produzido pelo folículo ovulatório. O aumento do estradiol provoca mudanças de comportamento e modificações na genitália externa e interna. A vaca mostra-se inquieta, sua vocalização aumenta, ela anda mais, tenta montar em outras vacas e aceita montar no touro ou em outra vaca, bem como urinam com mais frequência (micção frequente). A vulva fica levemente inflamada, à palpação retal o útero pode ser visto com tônus ou turgor (duro e contraído) e ao massagear o colo do útero observa-se que sai abundante muco cristalino da vulva. O mecanismo clássico proposto na regulação do estro é baseado principalmente no papel do estradiol; no entanto, estudos recentes indicam que o GnRH pode participar da regulação do estro ao nível do hipotálamo. O estro possui duração entre 8 e 18 horas e a intensidade do mesmo é afetada por fatores ambientais e intrínsecos a vaca moderna (figuras de 1 a 6). -/- -/- -/- Figura 2: A observação do grupo sexualmente ativo facilita a identificação das vacas em estro. -/- Figura 1: As vacas em estro formam grupos ativos (grupo sexualmente ativo) separados do resto das vacas. A conformação desses grupos facilita a observação do estro. -/- -/- A formação de grupos de vacas é um fator ideal para a detecção de vacas em cio, elas ficam juntas e começam a montar uma nas outras, a cheirar a urina de ambas etc. comportamentos que podem ser visualizados de longe pelo tratador e diagnosticado o cio o mais breve possível para o manejo reprodutivo adotado pela propriedade seja para monta natural ou controlada e/ou inseminações artificiais (IA) e artificiais em tempo fixo (IATF). -/- -/- Figura 3: O único comportamento positivo do estro é a aceitação da monta de outra vaca. É frequente que a vaca que realiza a monta também esteja em estro, o que só será afirmado até que ela aceite a monta de outra vaca. -/- -/- Figura 4: Cada monta dura de 5 a 7 segundos -/- Figura 5: A vaca leiteira aceita de 5 a 30 montas distribuídas entre 8 e 18 horas. -/- Figura 6: Além das mudanças comportamentais, os estrogênios causam alterações na genitália interna. Uma delas é a produção de muco cervical, que juntamente com o turgor uterino, constituem os sinais genitais do estro. -/- -/- O cio pode ser dividido em três fases, a inicial, a fase de cio verdadeiro e a fase final. O cio verdadeiro quando é observado, é caracterizado pelo momento em que a vaca aceita claramente a monta. Por sua vez, os sinais de início e final de cio se misturam, apresentam nervosismo e inquietação, cheiram e lambem a vagina e a urina de outras vacas, apoiam a cabeça na garupa de outras fêmeas etc. (figura 7). Uma das sugestões adotadas nas propriedades para facilitar a identificação do cio em um rebanho é realizada pelos funcionários com a utilização de um bastão ou fita de coloração da garupa das vacas. -/- Figura 7: Principais sinais que demonstram que a vaca está entrando em cio. As imagens mostram o início do cio, cio verdadeiro e final do cio. -/- CONTINUA. BAIXE O PDF!!! -/- RESUMO -/- -/- < >Nos Estados Unidos, 300 milhões de dólares são perdidos devido à baixa eficiência na detecção do estro. A eficiência na detecção do estro no Brasil é de 40 a 50%. A meta de eficiência para detecção de estro é > 60%. Com a observação das vacas em dois períodos diários de três horas cada (manhã e tarde), consegue-se uma eficiência na detecção de estro de 80%. Menos de 20 por cento das vacas devem ter um intervalo de serviço duplo e nenhum de mais de 48 dias. A taxa de prenhez é obtida multiplicando-se a eficiência na detecção do estro pela porcentagem de concepção e dividindo por 100 (50 * 30/100 = 15%). A taxa de prenhez em rebanhos norte-americanos é de 15%. Nos Estados Unidos, para cada ponto percentual que diminui a taxa de prenhez, não há mais de US$ 12 a US$ 15 por vaca por ano. No Brasil, para cada ponto percentual que aumenta a taxa de prenhez, na faixa de 15 a 20%, é gerada uma renda anual adicional de $ 190 reais por vaca. Não mais que 25% das vacas devem estar vazias no 150º dia pós-parto. Não mais do que 8% devem as vacas ser cobertas no 250º dia pós-parto. 8% das vacas devem engravidar a cada mês. O estro ocorre 48 a 120 horas após o tratamento com PGF2α. 80% é a precisão na palpação do corpo lúteo. Quatorze dias devem decorrer entre duas injeções de PGF2α. Menos de 25% das vacas incluídas no programa de pré-sincronização devem chegar à IATF. No momento da ovulação, a primeira injeção de GnRH deve ser aplicada entre o quinto e o nono dia do ciclo estral. A inseminação cronometrada é realizada 14-16 horas após a segunda injeção de GnRH. O tratamento com dispositivos intravaginais liberadores de progesterona dura 12 dias. Se a duração do tratamento é menor deve-se injetar PGF2α ao retirá-lo. -/- -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- -/- ATUESTA, Jorge; DIAZA, Angela Gonella. Control hormonal del ciclo estral en bovinos y ovinos. Spei Domus, v. 7, n. 14, 2011. -/- COLAZO, Marcos Germán; MAPLETOFT, Reben. Fisiología del ciclo estral bovino. Ciencia Veterinaria, v. 16, n. 2, p. 31-46, 2017. -/- Fisiologia Clínica do Ciclo Estral de Vacas Leiteiras: Desenvolvimento Folicular, Corpo Lúteo e Etapas do Estro. Belo Jardim: IFPE, 2020. -/- Fisiologia da Reprodução Animal: Ovulação, Controle e Sincronização do Cio. Belo Jardim: IFPE, 2020. -/- DOBSON, H. et al. The high‐producing dairy cow and its reproductive performance. Reproduction in domestic animals, v. 42, p. 17-23, 2007. -/- DO VALLE, Ezequlel Rodrigues. O ciclo estral de bovinos e métodos de controle. EMBRAPA-CNPGC., 1991. -/- FURTADO, Diego Augusto et al. Inseminação artificial em tempo fixo em bovinos de corte. Revista científica eletrônica de medicina veterinária, v. 16, p. 1-25, 2011. -/- GALON, Nadav. The use of pedometry for estrus detection in dairy cows in Israel. Journal of Reproduction and Development, v. 56, n. S, p. S48-S52, 2010. -/- HOPPER, Richard M. (Ed.). Bovine reproduction. John Wiley & Sons, 2014. -/- LOPEZ, H.; SATTER, L. D.; WILTBANK, M. C. Relationship between level of milk production and estrous behavior of lactating dairy cows. Animal reproduction science, v. 81, n. 3-4, p. 209-223, 2004. -/- MACMILLAN, Keith L. Recent advances in the synchronization of estrus and ovulation in dairy cows. Journal of Reproduction and development, v. 56, n. S, p. S42-S47, 2010. -/- MUNIS DE OLIVEIRA, G. Fisiologia da Reprodução Bovina e Métodos de Controle do Ciclo Estral. Trabalho de conclusão do curso de especialização em Reprodução e Produção de Bovinos–UCB. Rio de Janeiro, Brasil, 2006. -/- O'CONNOR, MICHAEL L. Estrus detection. In: Current therapy in large animal theriogenology. WB Saunders, 2007. p. 270-278. -/- RIPPE, Christian A. El ciclo estral. In: Dairy Cattle Reproduction Conference. 2009. p. 111-116. -/- ROELOFS, Judith et al. When is a cow in estrus? Clinical and practical aspects. Theriogenology, v. 74, n. 3, p. 327-344, 2010. -/- VIVEIROS, Ana Tereza de Mendonça. Fisiologia da reprodução de bovinos. Lavras: UFLA, p. 62, 1997. (shrink)

I argue that prioritarianism cannot be assessed in abstraction from an account of the measure of utility. Rather, the soundness of this view crucially depends on what counts as a greater, lesser, or equal increase in a person’s utility. In particular, prioritarianism cannot accommodate a normatively compelling measure of utility that is captured by the axioms of John von Neumann and Oskar Morgenstern’s expected utility theory. Nor can it accommodate a plausible and elegant generalization of this theory that has been (...) offered in response to challenges to von Neumann and Morgenstern. This is, I think, a theoretically interesting and unexpected source of difficulty for prioritarianism, which I explore in this article. (shrink)

Michael Sandel's opposition to the project of human enhancement is based on an argument that centres on the notion of giftedness. Sandel claims that by trying to ?make better people? we fall prey to, and encourage, an attitude of mastery and thus lose, or diminish, our appreciation of the giftedness of life. Sandel's position and the underlying argument have been much criticised. In this paper I will try to make sense of Sandel's reasoning and give an account of giftedness (...) that defends its relevance for the ethical assessment of the human enhancement project. In order to do so, I will also look at virtue-related notions, such as gratitude and humility, and distinguish the gifted from the merely given. The failure to acknowledge this distinction gives rise to one of the most common objections to Sandel's argument. Other objections will be shown to rest on similar misunderstandings. (shrink)

Active materials are self-propelled non-living entities which, in some circumstances, exhibit a number of cognitively interesting behaviors such as gradient-following, avoiding obstacles, signaling and group coordination. This has led to scientific and philosophical discussion of whether this may make them useful as minimal models of cognition (Hanczyc, 2014; McGivern, 2019). Batterman and Rice (2014) have argued that what makes a minimal model explanatory is that the model is ultimately in the same universality class as the target system, which underpins why (...) it exhibits the same macrobehavior. We appeal to recent research in basal cognition (Lyon et al., 2021) to establish appropriate target systems and essential features of cognition as a target of modeling. Looking at self-propelled oil droplets, a type of active material, we do not find that organization alone indicates that these systems exhibit the essential features of cognition. We then examine the specific behaviors of oil droplets but also fail to find that these demonstrate the essential features of cognition. Without a universality class, Batterman & Rice’s account of the explanatory power of minimal models simply does not apply to cognition. However, we also want to stress that it is not intended to; cognition is not the same type of behavioral phenomena as those found in physics. We then look to the minimal cognition methodology of Beer (1996, 2020a, b) to show how active materials can be explanatorily valuable regardless of their cognitive status because they engage in specific behaviors that have traditionally been expected to involve internal representational dynamics, revealing misconceptions about the cognitive underpinnings of certain, specific behaviors in target systems where such behaviors are cognitive. Further, Beer’s models can also be genuinely explanatory by providing dynamical explanations. (shrink)

Safety principles in epistemology are often hailed as providing us with an explanation of why we fail to have knowledge in Gettier cases and lottery examples, while at the same time allowing for the fact that we know the negations of sceptical hypotheses. In a recent paper, Sinhababu and Williams have produced an example—the Backward Clock—that is meant to spell trouble for safety accounts of knowledge. I argue that the Backward Clock case is, in fact, unproblematic for the more sophisticated (...) formulations of safety in the literature. However, I then proceed to construct two novel examples that turn out problematic for those formulations—one that provides us with a lottery-style case of safe ignorance and one that is a straightforward case of unsafe knowledge. If these examples succeed, then safety as it is usually conceived in the current debate cannot account for ignorance in all Gettier and lottery-style cases, and neither is it a necessary condition for knowledge. I conclude from these troublesome examples that modal epistemologists ought to embrace a much more simple and non-reductive version of safety, according to which the notion of similarity between possible worlds that determines in which worlds the subject must believe truly is an epistemic notion that cannot be defined or reduced to notions independent of knowledge. The resulting view is shown to also lead to desirable results with respect to lottery cases, certain quantum phenomena, and a puzzling case involving a cautious brain-in-a-vat. (shrink)

Why should a thought experiment, an experiment that only exists in people's minds, alter our fundamental beliefs about reality? After all, isn't reasoning from the imaginary to the real a sign of psychosis? A historical survey of how thought experiments have shaped our physical laws might lead one to believe that it's not the case that the laws of physics lie - it's that they don't even pretend to tell the truth. My aim in this paper is to defend an (...) account of thought experiments that fits smoothly into our understanding of the historical trajectory of actual thought experiments and that explains how any rational person could allow an imagined, unrealized (or unrealizable) situation to change their conception of the universe. (shrink)

When future historians chronicle the twentieth century, they will see phenomenology as one of the preeminent social and ethical philosophies of its age. The phenomenological movement not only produced systematic reflection on common moral concerns such as distinguishing right from wrong and explaining the status of values; it also called on philosophy to renew European societies facing crisis, an aim that inspired thinkers in interwar Europe as well as later communist bloc dissidents. Despite this legacy, phenomenology continues to be largely (...) discounted as esoteric and solipsistic, the last gasp of a Cartesian dream to base knowledge on the isolated rational mind. Intellectual histories tend to cite Husserl's epistemological influence on philosophies like existentialism and deconstruction without considering his social or ethical imprint. And while a few recent scholars have begun to note phenomenology's wider ethical resonance, especially in French social thought, its image as stubbornly academic continues to hold sway. _The Far Reaches_ challenges that image by tracing the first history of phenomenological ethics and social thought in Central Europe, from its founders Franz Brentano and Edmund Husserl through its reception in East Central Europe by dissident thinkers such as Jan Patocka, Karol Wojtyla, and Václav Havel. (shrink)

The idea that God creates out of Himself seems quite attractive. Many find great appeal in holding that a temporally finite universe must have a cause, but I think there’s also great appeal in holding that there’s pre-existent stuff out of which that universe is created—and what could that stuff be but part of God? Though attractive, the idea of creation ex deo hasn’t been taken seriously by theistic philosophers. Perhaps this is because it seems too vague—‘could anything enlightening be (...) said about what those parts are?’—or objectionable—‘wouldn’t creating out of those parts lessen or destroy God?’ Drawing from Stephen Kosslyn and Michael Tye’s work on the ontology of mental images, I respond to the above questions by developing a theory on which God creates the universe out of His mental imagery. (shrink)

In this brief review it is not possible to do full justice to this lively and lucidly presented study. It is fair to say, I think, that the considerable merits of this work rest primarily with its intelligent and reliable selection of material, most of which is already available and familiar. This study does not aim to challenge any orthodoxies or present new material of some significant kind. Rasmussen does not need to do this since his real concern is to (...) tell a story about two great thinkers in an engaging manner – a task which he achieves with great success. This is a book that scholars will thoroughly enjoy and appreciate and which will also find many appreciative readers well beyond these boundaries. (shrink)